anti- EXOSC5 antibody

Step into the realm of molecular biology with our Anti-EXOSC5 Antibody, a pioneering tool designed to enhance your research endeavors. EXOSC5, an essential subunit of the exosome complex, is a key player in RNA processing and degradation, making it a central focus for numerous studies. This premium polyclonal antibody, available in a convenient 100µg size, is the ideal companion for your scientific investigations.

Our Anti-EXOSC5 Antibody has undergone rigorous development and validation to ensure exceptional specificity and sensitivity. It empowers you to delve deep into the intricacies of EXOSC5's functions, including its involvement in RNA turnover, RNA quality control, and more. Rest assured, you can rely on this antibody for consistent and accurate results.

With a generous 100µg volume, this antibody minimizes the need for frequent reorders and maximizes your cost-efficiency. Whether you're examining EXOSC5 in cell lines, tissue samples, or other experimental setups, this antibody adapts seamlessly to a wide range of research applications.

Product Name

EXOSC5 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

IMMUNOGEN INFORMATION

Immunogen

exosome component 5

Synonyms

CML28, RRP46

Observed MW

28-30 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NQT4

IMAGES