anti- EXOSC7 antibody

Unlock the potential of your research with our Anti-EXOSC7 Antibody, a cutting-edge tool designed to elevate your molecular biology experiments. EXOSC7, a crucial component of the exosome complex, plays a fundamental role in RNA processing and degradation, making it a pivotal target for various studies. This high-quality polyclonal antibody, available in a convenient 100µg size, is the perfect partner for your research endeavors.

Our Anti-EXOSC7 Antibody has been meticulously developed and rigorously validated to ensure exceptional specificity and sensitivity. It offers you the confidence to explore EXOSC7's function in various biological contexts, including gene regulation, mRNA surveillance, and RNA turnover. With a focus on reproducibility and accuracy, this antibody is your key to obtaining reliable results in your experiments.

The 100µg size provides ample material for numerous assays, reducing the need for frequent reordering and ensuring cost-efficiency. Whether you're investigating EXOSC7 in cell culture, tissue samples, or other experimental systems, our antibody is a versatile tool that can be applied to diverse research areas.

Product Name

EXOSC7 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

IMMUNOGEN INFORMATION

Immunogen

exosome component 7

Synonyms

KIAA0116, RRP42

Observed MW

37 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q15024

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