anti- EZH2 antibody

Accelerate your epigenetic research with our Polyclonal Anti-EZH2 Antibody, a powerful tool designed to uncover the intricate mechanisms of gene regulation and chromatin remodeling. EZH2, a crucial component of the Polycomb repressive complex 2 (PRC2), plays a central role in histone methylation and transcriptional repression, making it a critical target for understanding various cellular processes. This high-quality antibody, available in a 100µg size, provides an abundant supply for your research needs, ensuring consistency and reproducibility in your experiments.

Our Polyclonal Anti-EZH2 Antibody has undergone rigorous development and validation to guarantee exceptional specificity and sensitivity. It empowers you to explore EZH2's multifaceted functions, including its involvement in stem cell differentiation, cancer progression, and more, with confidence in the reliability of your results.

The 100µg size minimizes the need for frequent reordering, enabling you to focus more on your research and less on supply management. Whether you're investigating epigenetic modifications, studying gene regulation, or exploring chromatin dynamics, this antibody seamlessly adapts to a variety of research applications, making it an invaluable asset in your scientific endeavors.

Product Name

EZH2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Polycomb group(PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9'(H3K9me) and 'Lys-27'(H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di-and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.

IMMUNOGEN INFORMATION

Immunogen

enhancer of zeste homolog 2(Drosophila)

Synonyms

Enhancer of zeste homolog 2, ENX 1, EZH1, EZH2, KMT6, Lysine N methyltransferase 6

Observed MW

90-102 kDa

APPLICATION

Tested Application

ELISA, WB, IP, IF

Recommended Dilution

WB: 1:1000-1:4000; IP: 1:500-1:3000; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q15910

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