anti- FANCA antibody

Unravel the mysteries of DNA repair and genomic stability with our Anti-FANCA Antibody, a critical tool for investigating the functions of Fanconi anemia complementation group A (FANCA). FANCA is a key player in the Fanconi anemia pathway, a vital mechanism for preserving genomic integrity. This high-quality antibody, available in a 100µg size, empowers you to delve into the intricacies of FANCA's roles.

Our Anti-FANCA Antibody has been meticulously developed and rigorously validated to ensure exceptional specificity and sensitivity. It enables you to explore FANCA's multifaceted functions, from its involvement in DNA repair to its implications in cancer, genetic disorders, and beyond, with confidence in the reliability of your results.

With 100µg at your disposal, this antibody minimizes the need for frequent reordering, ensuring a seamless and uninterrupted research experience. Whether you're unraveling the molecular details of DNA repair pathways, dissecting the impact of FANCA mutations, or exploring its potential in cancer therapy, this antibody seamlessly adapts to a wide range of research applications.

Product Name

FANCA antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.

IMMUNOGEN INFORMATION

Immunogen

Fanconi anemia, complementation group A

Synonyms

FAA, FACA, FANCH

Observed MW

163 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

O15360

IMAGES