anti- FANCD2 antibody

Delve into the intricate world of DNA repair and genomic stability with our Anti-FANCD2 Antibody, an essential tool for investigating the functions of Fanconi anemia complementation group D2 (FANCD2). FANCD2 is a central player in the Fanconi anemia pathway, a critical mechanism for preserving genomic integrity. This high-quality antibody, available in a 100µg size, is your trusted companion for exploring the intricacies of FANCD2's roles.

Our Anti-FANCD2 Antibody has been meticulously developed and rigorously validated to ensure exceptional specificity and sensitivity. It empowers you to explore FANCD2's multifaceted functions, from its involvement in DNA repair to its implications in cancer, genetic disorders, and beyond, with confidence in the reliability of your results.

With 100µg at your disposal, this antibody minimizes the need for frequent reordering, ensuring a seamless and uninterrupted research experience. Whether you're unraveling the molecular details of DNA repair, dissecting the impact of FANCD2 mutations, or exploring its potential in cancer therapy, this antibody seamlessly adapts to a wide range of research applications.

Product Name

FANCD2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.The antibody recognize both un-phospho and phospho-Ser(330) of FANCD2.

IMMUNOGEN INFORMATION

Immunogen

Fanconi anemia, complementation group D2

Synonyms

DKFZp762A223, FA D2, FA4, FACD, FAD, FAD2, FANCD, FANCD2, FLJ23826, Protein FACD2

Observed MW

150-155kd

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9BXW9

IMAGES