anti- FAS/CD95 antibody

Dive into the multifaceted world of FAS/CD95 with our Anti-FAS/CD95 Antibody, a versatile tool for researchers in immunology, apoptosis, and cancer biology. FAS/CD95, a prominent cell surface receptor known for its pivotal role in apoptosis, is the focus of this high-quality polyclonal antibody, available in a 100µg size. It provides the precision and sensitivity required to explore the functions and regulatory mechanisms of FAS/CD95.

This Anti-FAS/CD95 Polyclonal Antibody has been meticulously developed and rigorously validated to ensure its specificity and reliability. It empowers you to investigate FAS/CD95's role in programmed cell death, its interactions with ligands, and its potential applications in immunotherapy and cancer research.

With 100µg of this antibody at your disposal, you can minimize the need for frequent reordering, ensuring a smooth and uninterrupted research experience. Whether you are studying FAS/CD95's function in autoimmune diseases, its implications in cancer progression, or its contributions to drug development, this polyclonal antibody adapts effortlessly to a wide range of research applications.

Product Name

FAS/CD95 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

IMMUNOGEN INFORMATION

Immunogen

Fas (TNF receptor superfamily, member 6)

Synonyms

ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6

Observed MW

Refer to figures

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

P25445

IMAGES