anti- FBXO9 antibody

Delve into the intricacies of cellular regulation with our Anti-FBXO9 Antibody, available in a substantial 100µg size. FBXO9 is a key player in the ubiquitin-proteasome system, governing the degradation of specific proteins and influencing various cellular functions. This meticulously validated antibody serves as your window into the world of cellular dynamics.

Key Features:

1. 100µg Antibody Size: The generous 100µg quantity ensures you have an ample supply for a wide range of experiments, making your research cost-effective without compromising on reliability.

2. Rigorous Validation: Our Anti-FBXO9 Antibody has undergone comprehensive validation to confirm specificity and reliability, reducing the risk of non-specific interactions and ensuring accurate results.

3. Uncover Cellular Dynamics: Investigate FBXO9's role in regulating protein degradation, cellular dynamics, and its broader implications in cell biology, shedding light on potential connections with disease development.

4. Therapeutic Potential: Examine the potential links between FBXO9 and various diseases, offering fresh insights into therapeutic development and disease mechanisms.

5. Contribute to Scientific Progress: Join a community of leading researchers who rely on our Anti-FBXO9 Antibody to advance their understanding of regulatory proteins and their significance in maintaining healthy cell function.

Whether you're deciphering FBXO9's role in protein degradation or investigating its broader connections in cellular dynamics, our antibody guarantees precision and reliability in your research endeavors.

Product Name

FBXO9 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

IMMUNOGEN INFORMATION

Immunogen

F-box protein 9

Synonyms

FBX9, VCIA1

Observed MW

52 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9UK97

IMAGES