anti- FBXW11 antibody

Journey into the world of cellular control with our Anti-FBXW11 Antibody, available in a substantial 100µg size. FBXW11 is a pivotal component of the ubiquitin-proteasome system, playing a crucial role in the degradation of specific proteins and cell cycle regulation. This rigorously validated antibody is your key to understanding the intricate processes that maintain cellular balance.

Key Features:

1. 100µg Antibody Size: With 100µg of high-quality antibody, you have ample material for comprehensive experiments, ensuring cost-effective research without compromising on reliability.

2. Validation for Precision: Our Anti-FBXW11 Antibody has undergone thorough validation to confirm its specificity and reliability, reducing the risk of non-specific interactions and ensuring accurate results.

3. Explore Cellular Control: Investigate the significance of FBXW11 in regulating protein degradation, cell cycle control, and its broader implications in cell biology and disease development.

4. Potential Therapeutic Insights: Examine the potential connections between FBXW11 and various diseases, offering fresh perspectives for therapeutic development and insights into disease mechanisms.

5. Contribute to Scientific Progress: Join a community of leading researchers who rely on our Anti-FBXW11 Antibody to advance their understanding of cellular control and its significance in maintaining healthy cell function.

Whether you're deciphering FBXW11's role in protein degradation or investigating its broader connections in cellular control, our antibody ensures you achieve accurate and dependable results.

Product Name

FBXW11 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis(PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1(HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

IMMUNOGEN INFORMATION

Immunogen

F-box and WD repeat domain containing 11

Synonyms

BTRCP2, FBW1B, FBXW1B, KIAA0696

Observed MW

61 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q9UKB1

IMAGES