anti- FBXW5 antibody

Embark on a journey of discovery within the realm of cellular regulation with our Anti-FBXW5 Antibody, available in a substantial 100µg size. FBXW5 is a critical regulatory protein involved in the ubiquitin-proteasome system, contributing to the control of protein degradation and cell cycle progression. This meticulously validated antibody is your key to unlocking the world of cellular dynamics.

Key Features:

1. 100µg Antibody Size: The generous 100µg size ensures you have an ample supply for a wide range of experiments, making your research cost-effective without compromising on reliability.

2. Rigorous Validation: Our Anti-FBXW5 Antibody has undergone rigorous validation to confirm specificity and reliability, minimizing the risk of non-specific interactions and ensuring accurate results.

3. Delve into Cellular Dynamics: Investigate FBXW5's role in regulating protein degradation, cell cycle progression, and its broader implications in cell biology and disease development.

4. Therapeutic Potential: Examine the potential connections between FBXW5 and various diseases, offering fresh insights into therapeutic development and disease mechanisms.

5. Contribute to Scientific Progress: Join a community of leading researchers who rely on our Anti-FBXW5 Antibody to advance their understanding of regulatory proteins and their significance in cellular homeostasis.

Whether you're unraveling the specifics of FBXW5 in protein regulation or exploring its broader associations with diseases, our antibody guarantees precision and reliability in your research endeavors.

Product Name

FBXW5 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Substrate recognition component of both SCF(SKP1-CUL1-F-box protein) and DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B(IL1B) signaling pathway.

IMMUNOGEN INFORMATION

Immunogen

F-box and WD repeat domain containing 5

Synonyms

FBW5

Observed MW

65 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q969U6

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