anti- FBXW7 antibody

Dive into the intricate world of cellular regulation with our Anti-FBXW7 Antibody, available in a substantial 100µg size. FBXW7 is a critical component of the ubiquitin-proteasome system, playing a pivotal role in cell cycle control and tumor suppression. This meticulously validated antibody is your gateway to investigating the intricacies of cellular homeostasis.

Key Features:

1. 100µg Antibody Size: The generous 100µg quantity ensures you have an abundant supply for a wide range of experiments, enabling comprehensive research without compromising on reliability.

2. Rigorous Validation: Our Anti-FBXW7 Antibody has undergone thorough validation to verify specificity and reliability, reducing the risk of non-specific interactions and ensuring accurate results.

3. Exploring Cellular Homeostasis: Investigate the significance of FBXW7 in cell cycle regulation, tumor suppression, and its broader implications in cancer research and the development of targeted therapies.

4. Potential Therapeutic Insights: Discover the potential for developing targeted therapies by exploring the relationships between FBXW7 and various types of cancer, offering new avenues for treatment and insights into disease mechanisms.

5. Contribute to Scientific Progress: Join a community of leading researchers who rely on our Anti-FBXW7 Antibody to advance their understanding of cellular control and its significance in maintaining healthy cell function.

Whether you're unlocking the intricacies of FBXW7 in the cell cycle or investigating its broader implications in cancer biology, our antibody empowers you to conduct precise and dependable research.

Product Name

FBXW7 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

IMMUNOGEN INFORMATION

Immunogen

F-box and WD repeat domain containing 7

Synonyms

AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4

Observed MW

80 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

Q969H0

IMAGES