anti- FEN1 antibody

The Anti-FEN1 Antibody, available in a 100µg size, is your gateway to understanding the intricate world of DNA repair mechanisms. With its high specificity and versatility, this antibody is an indispensable tool for researchers exploring the vital roles of FEN1 (Flap Endonuclease 1) in genome maintenance.

Key Features:

1. Comprehensive DNA Repair Research: FEN1 plays a crucial role in DNA repair pathways, ensuring the integrity of your genetic material. With our high-quality antibody, you can delve deep into the world of DNA repair, from base excision repair to Okazaki fragment maturation.

2. Size Matters: The 100µg size offers ample antibody for a multitude of experiments, providing value for your research investment.

3. Exceptional Specificity: This antibody has undergone rigorous validation, ensuring that it specifically recognizes FEN1. Your results will be reliable and reproducible, supporting the integrity of your research.

4. Diverse Research Applications: Explore FEN1's functions in DNA repair, replication, and its relevance to human diseases. Investigate its potential as a therapeutic target in various genetic disorders.

5. Contributing to Disease Understanding: Research into FEN1 can shed light on the molecular underpinnings of conditions like cancer and neurodegenerative diseases, offering hope for future treatments.

6. Invaluable Tool for Molecular Biology: Whether you are studying protein-protein interactions, enzymatic activities, or genetic stability, this antibody is a cornerstone for a wide range of molecular biology studies.

7. Expert Support: Join the ranks of researchers worldwide who have successfully employed our Anti-FEN1 Antibody in their groundbreaking studies.

Product Name

FEN1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

IMMUNOGEN INFORMATION

Immunogen

flap structure-specific endonuclease 1

Synonyms

RAD2

Observed MW

42 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF, IP

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100; IP : 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P39748

IMAGES