anti- FGFR1 antibody

Introducing our Anti-FGFR1 Antibody, a powerful monoclonal antibody available in a 100µg size. FGFR1 is a vital member of the FGFR family, known for its role in cellular signaling, growth regulation, and tissue development. This monoclonal antibody offers precise targeting, versatility, and the highest standards of specificity, making it an ideal tool for researchers.

Key Features:

• Monoclonal Precision: This antibody provides the advantages of monoclonal antibodies, ensuring the highest level of specificity and consistency for your experiments.
• Rigorous Specificity: Our Anti-FGFR1 Antibody is thoroughly tested to ensure accurate and reliable results while minimizing cross-reactivity.
• Generous Quantity: The 100µg size guarantees you have an ample supply for multiple experiments, optimizing cost-effectiveness.
• Superior Quality: Manufactured to industry-leading standards, this antibody assures consistent and reproducible results.
• Elevate Your Research: Whether your focus is on cellular signaling, growth regulation, or tissue development, our Anti-FGFR1 Antibody empowers your research with monoclonal precision.

Uncover valuable insights and unlock the potential of your research with our Anti-FGFR1 Antibody.

Product Name

FGFR1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone(GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

IMMUNOGEN INFORMATION

Immunogen

fibroblast growth factor receptor 1

Synonyms

BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR

Observed MW

90 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, FC

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

P11362

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