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Immunohistochemistry of paraffin-embedded mouse liver using FNab03131(FIP1L1 antibody) at dilution of 1:50 -
K-562 cells were subjected to SDS PAGE followed by western blot with FNab03131(FIP1L1 antibody) at dilution of 1:1000
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FineTest
SKU:FNab03131
anti- FIP1L1 antibody
anti- FIP1L1 antibody
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$310.00 USD
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Investigate the function of FIP1L1 with our Anti-FIP1L1 Antibody, available in a 100µg vial. FIP1L1, a key protein involved in hematopoiesis, is known for its association with certain blood disorders. This highly specific antibody empowers researchers to explore the functions of FIP1L1 in detail, contributing to a deeper understanding of its involvement in hematopoietic processes.
Key Features:
- Exceptional Specificity: Our Anti-FIP1L1 Antibody is rigorously tested to ensure it accurately targets FIP1L1, minimizing the risk of cross-reactivity.
- Versatile Applications: Ideal for a wide range of experimental techniques, including immunohistochemistry, Western blotting, and immunoprecipitation.
- Ample Quantity: With 100µg, you have a generous supply for multiple experiments.
- Top-Tier Quality: Manufactured to the highest industry standards, guaranteeing consistent and reproducible results.
- Advance Your Research: Whether you're studying hematopoiesis, blood disorders, or related processes, our Anti-FIP1L1 Antibody is your key to unraveling new knowledge.
Investigate the function of FIP1L1 in hematopoietic processes and elevate your research with our Anti-FIP1L1 Antibody.
Product Name
FIP1L1 antibody
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
BACKGROUND
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
IMMUNOGEN INFORMATION
Immunogen
FIP1 like 1
Synonyms
FIP1, RHE
Observed MW
75 kDa
APPLICATION
Tested Application
ELISA, WB, IHC, IF
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
UNIPROT INFORMATION
UniProt ID
IMAGES
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