anti- FOXA2 antibody

Delve into the functions of Forkhead Box A2 (FOXA2) with our Anti-FOXA2 Antibody, available in a 100µg vial. FOXA2 is a transcription factor that plays a crucial role in various cellular processes, including organ development and metabolism. This highly specific antibody empowers researchers to investigate FOXA2 and its roles, contributing to a deeper understanding of its impact on development and health.

Key Features:

• Exceptional Specificity: Our Anti-FOXA2 Antibody is rigorously tested to ensure it accurately targets FOXA2, minimizing the risk of cross-reactivity.
• Versatile Applications: Ideal for various experimental techniques, including immunohistochemistry, Western blotting, and ChIP assays.
• Ample Quantity: With 100µg, you have a generous supply for multiple experiments.
• Top-Tier Quality: Manufactured to the highest industry standards, guaranteeing consistent and reproducible results.
• Advance Your Research: Whether you're studying organ development, metabolism, or related fields, our Anti-FOXA2 Antibody is your key to delving into the functions of FOXA2.

Product Name

FOXA2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'(By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

IMMUNOGEN INFORMATION

Immunogen

forkhead box A2

Synonyms

forkhead box A2, Forkhead box protein A2, FOXA2, HNF 3 beta, HNF 3B, HNF3B, TCF 3B, TCF3B, Transcription factor 3B

Observed MW

60 kDa

APPLICATION

Tested Application

ELISA, IP, WB, IHC

Recommended Dilution

WB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q9Y261

IMAGES