anti- FOXO1 antibody

Uncover the regulatory role of Forkhead Box O1 (FOXO1) with our Anti-FOXO1 Antibody, available in two 100µg vials. FOXO1 is a transcription factor associated with various cellular processes, including cell cycle regulation and apoptosis. This highly specific antibody empowers researchers to explore FOXO1's functions, contributing to a deeper understanding of its impact on cell biology and disease mechanisms.

Key Features:

• Exceptional Specificity: Our Anti-FOXO1 Antibody is rigorously tested to ensure it accurately targets FOXO1, minimizing the risk of cross-reactivity.
• Ample Quantity: With two 100µg vials, you have a generous supply for multiple experiments.
• Versatile Applications: Ideal for various experimental techniques, including immunohistochemistry, Western blotting, and ChIP assays.
• Top-Tier Quality: Manufactured to the highest industry standards, guaranteeing consistent and reproducible results.
• Advance Your Research: Whether you're studying cell cycle regulation, insulin signaling, or related fields, our Anti-FOXO1 Antibody is your key to uncovering FOXO1's regulatory role.

Product Name

FOXO1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element(IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element(DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

IMMUNOGEN INFORMATION

Immunogen

forkhead box O1

Synonyms

FKHR, FOXO1A

Observed MW

70 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q12778

IMAGES