anti- GABBR1 antibody

Delve into the intricate world of neuronal signaling and synaptic transmission with our Anti-GABBR1 Antibody, available in a 100µg size. GABBR1 (Gamma-Aminobutyric Acid Type B Receptor Subunit 1) is a pivotal subunit of GABA(B) receptors, playing a crucial role in mediating the effects of the inhibitory neurotransmitter GABA. This antibody is meticulously designed to specifically target GABBR1, enabling you to study its functions with precision.

Key Features:

• Precise Targeting: Rigorously validated to exclusively recognize GABBR1, reducing the risk of non-specific binding to other proteins.
• Versatile Applications: Suitable for various experimental techniques, including Western blotting, immunofluorescence, and immunoprecipitation, empowering your research in neurobiology and neuronal signaling.
• Adequate Quantity: With 100µg of antibody, you have enough material for multiple experiments, reducing the need for frequent restocking.
• Quality Guaranteed: Manufactured under stringent quality control measures to ensure the consistency and reliability of your results.
• Unveil Brain Function: Whether you're investigating GABBR1's role in epilepsy, anxiety disorders, or synaptic plasticity, our Anti-GABBR1 Antibody is your indispensable tool.

If you would like more information about any specific antibody or have any other questions, please feel free to ask.

Product Name

GABBR1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins(G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium(Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by(-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

IMMUNOGEN INFORMATION

Immunogen

gamma-aminobutyric acid(GABA) B receptor, 1

Synonyms

GABBR1, GABABR1, GABBR1-3, GB1, GPRC3A, gamma-aminobutyric acid type B receptor subunit 1

Observed MW

95 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q9UBS5

IMAGES