anti- GEMIN4 antibody

Explore the complexities of RNA processing and spliceosome assembly with our Anti-GEMIN4 Antibody. This essential research tool enables you to delve into GEMIN4-related studies. Key features include:

• High Specificity: Each 100µg vial contains antibodies meticulously designed to specifically target Gem-associated protein 4 (GEMIN4), ensuring the accuracy and reliability of your experiments.
• Enhanced Sensitivity: This antibody is highly sensitive, ideal for detecting GEMIN4 in various experimental setups, from Western blotting to immunoprecipitation.
• Versatile Applications: Suitable for investigating RNA splicing, small nuclear ribonucleoprotein complexes (snRNPs), and RNA transport, this antibody accommodates a range of research methodologies.
• RNA Insights: Gain valuable insights into GEMIN4's role in RNA metabolism, its significance in spliceosome assembly, and its implications in various RNA-related disorders.

Elevate your studies in RNA biology and splicing mechanisms with our Anti-GEMIN4 Antibody, your gateway to understanding the intricacies of RNA processing.

Product Name

GEMIN4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins(snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

IMMUNOGEN INFORMATION

Immunogen

gem(nuclear organelle) associated protein 4

Observed MW

120-130 kDa

APPLICATION

Tested Application

ELISA, WB, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:2000

UNIPROT INFORMATION

UniProt ID

P57678

IMAGES