anti- GEMIN5 antibody

Illuminate the intricate role of Gem-associated Protein 5 (GEMIN5) in RNA processing and cellular functions with our Anti-GEMIN5 Antibody. This meticulously crafted research tool is designed to provide you with precision and specificity in your experiments. Key features include:

• High Specificity: Our antibody is specifically engineered to target GEMIN5, ensuring accurate and reliable results in your research. It recognizes GEMIN5 with exceptional specificity, allowing for confident data interpretation.

• RNA Processing Insights: Gain valuable insights into GEMIN5's role in small nuclear ribonucleoprotein assembly (snRNP), its potential implications in mRNA splicing, and its significance in cellular RNA processing.

• Versatile Sizing: The 100µg size is ideal for multiple experiments while ensuring product freshness and quality.

• Broad Applications: This antibody is suitable for various research methodologies, from studying RNA-related processes to exploring GEMIN5's interactions with other RNA-binding proteins.

Empower your research in the fields of RNA biology, cellular functions, and mRNA splicing, unraveling the role of GEMIN5 in RNA processing.

Please let me know if you would like any adjustments or further information for these product descriptions.

Product Name

GEMIN5 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins(snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.

IMMUNOGEN INFORMATION

Immunogen

gem(nuclear organelle) associated protein 5

Observed MW

168 kDa

APPLICATION

Tested Application

ELISA, WB, IP, IF, IHC

Recommended Dilution

WB: 1:500-1:3000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q8TEQ6

IMAGES