anti- GLRA1 antibody

Embark on a journey into the world of glycine receptor alpha-1 (GLRA1) and its pivotal roles in neurobiology, neurotransmission, and receptor research with our highly specific Anti-GLRA1 Antibody. Key features of this research tool include:

• High Specificity: This antibody is meticulously engineered to specifically target GLRA1, ensuring accuracy and reliability in your research. It recognizes GLRA1 with remarkable specificity, facilitating precise data interpretation.

• Neurobiology Insights: Explore GLRA1's involvement in inhibitory neurotransmission, its potential implications in neurological disorders, and its significance in understanding synaptic processes.

• Optimal Size: The 100µg quantity offers ample reagent for multiple experiments while maintaining product freshness and quality.

• Broad Applications: This antibody is suitable for various research methodologies, whether you're studying neuronal signaling, synaptic transmission, or GLRA1's interactions with other receptor subunits.

Elevate your research in the fields of neurobiology, neuroscience, and receptor function as you uncover the diverse roles of GLRA1.

Product Name

GLRA1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Glycine receptors are ligand-gated chloride channels(PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine(PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine(PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization(PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability(PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents(PubMed:25445488). Channel activity is potentiated by ethanol(PubMed:25973519). Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol(By similarity).

IMMUNOGEN INFORMATION

Immunogen

glycine receptor, alpha 1

Observed MW

48 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

P23415

IMAGES

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab03486(GLRA1 antibody) at dilution of 1:500