anti- GRB14 antibody

anti- GRB14 antibody

Product Name

GRB14 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor(INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

IMMUNOGEN INFORMATION

Immunogen

growth factor receptor-bound protein 14

Observed MW

61kd

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q14449

IMAGES

Immunohistochemistry of paraffin-embedded human ovary tumor using FNab03641(GRB14 antibody) at dilution of 1:50

DU 145 cells were subjected to SDS PAGE followed by western blot with FNab03641(GRB14 Antibody) at dilution of 1:600