anti- HDAC1 antibody

anti- HDAC1 antibody

Product Name

HDAC1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones(H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase(HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

IMMUNOGEN INFORMATION

Immunogen

histone deacetylase 1

Synonyms

DKFZp686H12203, GON 10, HD1, HDAC1, histone deacetylase 1, RPD3, RPD3L1

Observed MW

60 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:10000 - 1:50000; IHC: 1:100 - 1:200; IF: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

Q13547

IMAGES

Immunohistochemistry of paraffin-embedded human lung cancer using FNab03793(HDAC1 antibody) at dilution of 1:200

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab03793(HDAC1 antibody) at dilution of 1:30000