anti- HDAC3 antibody

anti- HDAC3 antibody

Product Name

HDAC3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

IMMUNOGEN INFORMATION

Immunogen

histone deacetylase 3

Synonyms

HD3

Observed MW

47 kDa

APPLICATION

Tested Application

ELISA, IHC, IP, WB, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:200; IP: 1:50 - 1:200; ChIP: 1:20 - 1:100

UNIPROT INFORMATION

UniProt ID

O15379

IMAGES

Immunohistochemistry of paraffin-embedded human esophagus using FNab03798(HDAC3 antibody) at dilution of 1:100

IP Result of anti-HDAC3 (IP:FNab03798, 3ug; Detection:FNab03798 1:300) with A431 cells lysate 1200ug.

HL-60 cells were subjected to SDS PAGE followed by western blot with FNab03798( HDAC3 Antibody) at dilution of 1:1000