anti- HEY1 antibody

anti- HEY1 antibody

Product Name

HEY1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).

IMMUNOGEN INFORMATION

Immunogen

hairy/enhancer-of-split related with YRPW motif 1

Synonyms

BHLHB31, CHF2, HERP2, HESR1, HRT1

Observed MW

33 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9Y5J3

IMAGES

Immunohistochemistry of paraffin-embedded human brain using FNab03849(HEY1 antibody) at dilution of 1:100

IP Result of anti-HEY1 (IP:FNab03849, 4ug; Detection:FNab03849 1:500) with mouse kidney tissue lysate 4400ug.

DU 145 cells were subjected to SDS PAGE followed by western blot with FNab03849(HEY1 antibody) at dilution of 1:3000