anti- HOMER1 antibody

anti- HOMER1 antibody

Product Name

HOMER1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

IMMUNOGEN INFORMATION

Immunogen

homer homolog 1(Drosophila)

Synonyms

SYN47

Observed MW

46-48 kDa

APPLICATION

Tested Application

ELISA, WB, FC, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q86YM7

IMAGES

Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab03963(HOMER1 Antibody) at dilution of 1:50

IP result of anti-HOMER1(IP:FNab03963, 4ug; Detection:FNab03963 1:1000) with fetal human brain tissue lysate 4000 ug

human brain tissue were subjected to SDS PAGE followed by western blot with FNab03963(HOMER1 antibody) at dilution of 1:1000