anti- HSD3B7 antibody

anti- HSD3B7 antibody

Product Name

HSD3B7 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis(PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol(7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.

IMMUNOGEN INFORMATION

Immunogen

hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 7

Observed MW

36 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9H2F3

IMAGES

Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab04032(HSD3B7 antibody) at dilution of 1:50

mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab04032(HSD3B7 antibody) at dilution of 1:500