anti- HSP90 antibody

anti- HSP90 antibody

Product Name

HSP90 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

HSP90, encoded by HSP90AA1, is a constitutively and ubiquitously expressed molecular chaperone that is crucial for the stability and function of many proteins. HSP90 provides chaperoning activity for client proteins; many of them are members of oncogenic pathways, indicating its implication in tumor malignancy. HSP90 mainly resides in the cytosol, while it can also be released to the extracellular space. Secreted Hsp90 is a C-terminal truncated form. It has been reported that the level of plasma Hsp90 is positively correlated with tumor malignancy in clinical cancer patients, and can be a promising diagnostic marker for tumor malignancy in clinical application.

IMMUNOGEN INFORMATION

Immunogen

heat shock protein 90kDa alpha(cytosolic), class A member 1

Synonyms

HSP 86, HSP86, Hsp89, HSP89A, HSP90, HSP90A, HSP90AA1, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2

Observed MW

90 kDa

APPLICATION

Tested Application

ELISA, IF, IHC, IP, WB, FC

Recommended Dilution

WB: 1:1000-1:6000

IP:1:500-1:1000

IHC: 1:20-1:200

IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P07900

IMAGES

Immunohistochemistry of paraffin-embedded human liver cancer using FNab04051(HSP90 antibody) at dilution of 1:50

IP Result of anti-HSP90 (IP: FNab04051, 4ug; Detection: FNab04051 1:500) with K-562 cells lysate 4000ug.

HeLa cells were subjected to SDS PAGE followed by western blot with FNab04051(HSP90 Antibody) at dilution of 1:3000