anti- ICAM-1 antibody

anti- ICAM-1 antibody

Product Name

ICAM-1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

ICAM-1 (CD54) is a 90-kDa transmembrane glycoprotein of the immunoglobulin superfamily and is critical for the firm attachment and transmigration of leukocytes out of blood vessels and into tissues (PMID: 19307690). ICAM-1 is expressed by several cell types, typically on endothelial cells and cells of the immune system, and its expression can be up-regulated by various stimuli, including TNF-α, INF-γ, IL-1 and thrombin (PMID: 3086451; 9694714; 15979056). It is a ligand for LFA-1 and Mac-1, serves as a receptor for rhinovirus, and is one of several receptors used by Plasmodium falciparum (PMID: 2566624; 2538244; 2475784).

IMMUNOGEN INFORMATION

Immunogen

intercellular adhesion molecule 1

Synonyms

BB2, CD54, ICAM 1, ICAM1, ICAM-1, P3.58

Observed MW

85-95 kDa

APPLICATION

Tested Application

ELISA, IHC, WB, FC

Recommended Dilution

WB: 1:1000-1:4000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

P05362

IMAGES

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab04103(ICAM-1 Antibody) at dilution of 1:50.heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Raji cells were subjected to SDS PAGE followed by western blot with FNab04103(ICAM-1 Antibody) at dilution of 1:2000