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Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab04170(IGF1R-Specific antibody) at dilution of 1:100 -
Immunofluorescence analysis of NIH/3T3 cells using FNab04170 (IGF1R-Specific antibody) at dilution of 1:100. Blue: DAPI for nuclear staining. -
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab04170(IGF1R-Specific antibody) at dilution of 1:1000
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SKU:FNab04170
anti- IGF1R antibody
anti- IGF1R antibody
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anti- IGF1R antibody
Product Name
IGF1R antibody
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
BACKGROUND
IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. IGF1R is a heterotetrameric receptor, composed of two alpha subunits (130 kDa each) and two beta subunits (~98 kDa each) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds.
IMMUNOGEN INFORMATION
Immunogen
insulin-like growth factor 1 receptor
Synonyms
CD221, IGFIR, IGFR, JTK13
Observed MW
70 kDa,90-100 kDa, 130 kDa
APPLICATION
Tested Application
ELISA, WB, IHC, IF
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
UNIPROT INFORMATION
UniProt ID
IMAGES
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