anti- KIF7 antibody

anti- KIF7 antibody

Product Name

KIF7 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog(Shh) and Indian hedgehog(Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and-independent mechanisms(PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes(By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation(By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development(By similarity).

IMMUNOGEN INFORMATION

Immunogen

kinesin family member 7

Synonyms

KIF7, kinesin family member 7, Kinesin like protein KIF7, UNQ340

Observed MW

150 kDa

APPLICATION

Tested Application

ELISA, IP, WB

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:1000

UNIPROT INFORMATION

UniProt ID

Q2M1P5

IMAGES

IP Result of anti-KIF7 (IP: FNab04570, 4ug; Detection: FNab04570 1:500) with HEK-293 cells lysate 2000ug.

HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab04570( KIF7 Antibody) at dilution of 1:1000