anti- KPNA6 antibody

anti- KPNA6 antibody

Product Name

KPNA6 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.

IMMUNOGEN INFORMATION

Immunogen

karyopherin alpha 6 (importin alpha 7)

Synonyms

IPOA7

Observed MW

60 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

O60684

IMAGES

Immunohistochemistry of paraffin-embedded human kidney using FNab04638( KPNA6 Antibody) at dilution of 1:100 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

BxPC-3 cells were subjected to SDS PAGE followed by western blot with FNab04638( KPNA6 Antibody) at dilution of 1:1000