anti- LATS1 antibody

anti- LATS1 antibody

Product Name

LATS1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

IMMUNOGEN INFORMATION

Immunogen

LATS, large tumor suppressor, homolog 1

Synonyms

LATS1, WARTS, WARTS protein kinase, wts

Observed MW

140 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O95835

IMAGES

Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab04708(LATS1 Antibody) at dilution of 1:50

K562 tissue were subjected to SDS PAGE followed by western blot with FNab04708(LATS1 antibody) at dilution of 1:500

RELATED PRODUCTS

• Recombinant Human LATS1
• Human LATS1(Serine/threonine-protein kinase LATS1) ELISA Kit

STATEMENT

Manuals on the web are for your reference only, specifications are subject to the delivery manuals.

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