anti- LGR6 antibody

anti- LGR6 antibody

Product Name

LGR6 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

IMMUNOGEN INFORMATION

Immunogen

leucine-rich repeat-containing G protein-coupled receptor 6

Synonyms

FLJ14471, GPCR, LGR6, VTS20631

Observed MW

104 kDa

APPLICATION

Tested Application

ELISA, IHC, WB, FC

Recommended Dilution

WB: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9HBX8

IMAGES

Immunohistochemistry of paraffin-embedded human testis using FNab04766(LGR6 antibody) at dilution of 1:50

mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab04766(LGR6 antibody) at dilution of 1:100