anti- LIN7A antibody

anti- LIN7A antibody

Product Name

LIN7A antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7(LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B(subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter(SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

IMMUNOGEN INFORMATION

Immunogen

lin-7 homolog A(C. elegans)

Synonyms

MALS1, VELI1

Observed MW

28-30 kDa

APPLICATION

Tested Application

ELISA, WB, IP, IHC

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O14910

IMAGES

Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab04788(LIN7A Antibody) at dilution of 1:50

IP Result of anti-LIN7A (IP:FNab04788, 3ug; Detection:FNab04788 1:1000) with mouse brain tissue lysate 4000ug.

rat brain tissue were subjected to SDS PAGE followed by western blot with FNab04788(LIN7A Antibody) at dilution of 1:1000