anti- LONP1 antibody

anti- LONP1 antibody

Product Name

LONP1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory(StAR) protein.

IMMUNOGEN INFORMATION

Immunogen

lon peptidase 1, mitochondrial

Synonyms

PRSS15

Observed MW

100 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:10000; IHC: 1:400-1:1600; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P36776

IMAGES

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab04821(LONP1 Antibody) at dilution of 1:800 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04821(LONP1 Antibody) at dilution of 1:5000