anti- MBNL3 antibody

anti- MBNL3 antibody

Product Name

MBNL3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T(TNNT2) pre-mRNA exon inclusion but induces insulin receptor(IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology(DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.

IMMUNOGEN INFORMATION

Immunogen

muscleblind-like 3(Drosophila)

Synonyms

CHCR, MBLX39, MBXL

Observed MW

38 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NUK0

IMAGES

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using FNab05041(MBNL3 Antibody) at dilution of 1:50

mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab05041(MBNL3 Antibody) at dilution of 1:600