anti- MDC1 antibody

anti- MDC1 antibody

Product Name

MDC1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

IMMUNOGEN INFORMATION

Immunogen

mediator of DNA damage checkpoint 1

Synonyms

KIAA0170, NFBD1

Observed MW

270 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

UNIPROT INFORMATION

UniProt ID

Q14676

IMAGES

Immunohistochemistry of paraffin-embedded human prostate cancer using FNab05072(MDC1 Antibody) at dilution of 1:100

HeLa cells were subjected to SDS PAGE followed by western blot with FNab05072(MDC1 antibody) at dilution of 1:1000