anti- MEK5 antibody

anti- MEK5 antibody

Product Name

MEK5 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms(aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

IMMUNOGEN INFORMATION

Immunogen

mitogen-activated protein kinase kinase 5

Synonyms

HsT17454, MAP kinase kinase 5, MAP2K5, MAPK/ERK kinase 5, MAPKK 5, MAPKK5, MEK 5, MEK5, MKK5, PRKMK5

Observed MW

50kd

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:100

UNIPROT INFORMATION

UniProt ID

Q13163

IMAGES

Immunohistochemistry of paraffin-embedded human heart using FNab05117(MAP2K5 antibody) at dilution of 1:50

Immunofluorescent analysis of U2OS cells, using MAP2K5 antibody FNab05117 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

HeLa cells were subjected to SDS PAGE followed by western blot with FNab05117(MAP2K5 antibody) at dilution of 1:500