anti- MEN1 antibody

anti- MEN1 antibody

Product Name

MEN1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Essential component of a MLL/SET1 histone methyltransferase(HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3(H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression(By similarity). May be involved in DNA repair.

IMMUNOGEN INFORMATION

Immunogen

multiple endocrine neoplasia I

Synonyms

SCG2

Observed MW

63-70 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

O00255

IMAGES

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab05123(MEN1 antibody) at dilution of 1:500