anti- MFN2 antibody

anti- MFN2 antibody

Product Name

MFN2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy(mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response(UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.

IMMUNOGEN INFORMATION

Immunogen

mitofusin 2

Synonyms

CMT2A, CMT2A2, CPRP1, HSG, KIAA0214, MARF, MFN2, Mitofusin 2, Transmembrane GTPase MFN2

Observed MW

86 kDa

APPLICATION

Tested Application

ELISA, WB, IP, IHC

Recommended Dilution

IP: 1:200-1:1000; WB: 1:200-1:1000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

O95140

IMAGES

Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab05151(MFN2 Antibody) at dilution of 1:200

IP result of anti-MFN2(IP:FNab05151, 4ug; Detection:FNab05151 1:300) with mouse kidney tissue lysate 3000 ug

mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab05151(MFN2 antibody) at dilution of 1:500

RELATED PRODUCTS

• Mouse Mfn2(Mitofusin-2)ELISA Kit
• Human MFN2(Mitofusin-2) ELISA Kit

STATEMENT

Manuals on the web are for your reference only, specifications are subject to the delivery manuals.

FEATURED PRODUCT