anti- MGME1 antibody

anti- MGME1 antibody

Product Name

MGME1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Metal-dependent single-stranded DNA(ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA(mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine(5hmC)-containing DNA in stem cells.

IMMUNOGEN INFORMATION

Immunogen

chromosome 20 open reading frame 72

Synonyms

C20orf72, DDK1

Observed MW

36-39 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9BQP7

IMAGES

Immunohistochemistry of paraffin-embedded human kidney slide using FNab05168(MGME1 Antibody) at dilution of 1:50

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab05168(MGME1 antibody) at dilution of 1:1000