anti- MICAL2 antibody

anti- MICAL2 antibody

Product Name

MICAL2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

IMMUNOGEN INFORMATION

Immunogen

microtubule associated monoxygenase, calponin and LIM domain containing 2

Synonyms

KIAA0750, MICAL2PV1, MICAL2PV2

Observed MW

95, 112 kDa

APPLICATION

Tested Application

ELISA, IHC, IF

Recommended Dilution

IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O94851

IMAGES

Immunohistochemistry of paraffin-embedded human stomach cancer slide using FNab05178(MICAL2 Antibody) at dilution of 1:50