anti- MMP12 antibody

anti- MMP12 antibody

Product Name

MMP12 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275).

IMMUNOGEN INFORMATION

Immunogen

matrix metallopeptidase 12(macrophage elastase)

Synonyms

HME, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase 12, ME, MME, MMP 12, MMP12

Observed MW

54 kDa, 45 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P39900

IMAGES

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab05234(MMP12 Antibody) at dilution of 1:50

Immunofluorescent analysis of ( -20℃ Ethanol ) fixed A549 cells using FNab05234 (MMP12 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05234(MMP12 Antibody) at dilution of 1:600

RELATED PRODUCTS

• P2576
• Rat MMP-12(Matrix Metalloproteinase 12) ELISA Kit
• Mouse MMP-12(Matrix Metalloproteinase 12) ELISA Kit
• Human MMP-12(Macrophage metalloelastase) ELISA Kit

STATEMENT

Manuals on the web are for your reference only, specifications are subject to the delivery manuals.

FEATURED PRODUCT