anti- MVP/LRP antibody

anti- MVP/LRP antibody

Product Name

MVP/LRP antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.

IMMUNOGEN INFORMATION

Immunogen

major vault protein

Synonyms

LRP, major vault protein, MVP, VAULT1

Observed MW

100 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

Q14764

IMAGES

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab05449( MVP Antibody) at dilution of 1:200

Immunofluorescence analysis of U2OS cells using FNab05449( MVP Antibody) at dilution of 1:100. Blue: DAPI for nuclear staining.

SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab05449(MVP antibody) at dilution of 1:1000