anti- PDE9A antibody

PRODUCT INFORMATION

Product Name

PDE9A antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP(PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart(PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein(Probable). In brain, involved in cognitive function, such as learning and long-term memory(By similarity).

IMMUNOGEN INFORMATION

Immunogen

phosphodiesterase 9A

Synonyms

HSPDE9A2, PDE9A, phosphodiesterase 9A

APPLICATION

Tested Application

ELISA, IF, IHC

Recommended Dilution

IHC: 1:100-1:200; IF: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

O76083

Immunofluorescent analysis of ( -20℃ Ethanol ) fixed A549 cells using FNab06263 (PDE9A antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)