anti- Piezo1 antibody

PRODUCT INFORMATION

Product Name

Piezo1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).

IMMUNOGEN INFORMATION

Immunogen

family with sequence similarity 38, member A

Synonyms

FAM38A, KIAA0233

Observed MW

250kd

APPLICATION

Tested Application

ELISA, WB,IHC

Recommended Dilution

WB: 1:200-1:1000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q92508

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06435(Piezo1 antibody) at dilution of 1:500