anti- PKC epsilon antibody

PRODUCT INFORMATION

Product Name

PKC epsilon antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.

IMMUNOGEN INFORMATION

Immunogen

protein kinase C, epsilon

Synonyms

PKCE, nPKC-epsilon

Observed MW

90kDa

APPLICATION

Tested Application

ELISA, WB, IHC, ICC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; ICC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

Q02156

mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab06484 (PKC epsilon antibody) at dilution of 1:1000