anti- PTGES3 antibody

anti- PTGES3 antibody

Product Name

PTGES3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2(PGH2) to prostaglandin E2(PGE2)(PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes(PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway(PubMed:24711448).

IMMUNOGEN INFORMATION

Immunogen

prostaglandin E synthase 3(cytosolic)

Synonyms

P23, TEBP

Observed MW

21-23 kDa

APPLICATION

Tested Application

ELISA, IF, IP, WB, FC

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:2000; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q15185

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