anti- RIC8A antibody

anti- RIC8A antibody

Product Name

RIC8A antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Guanine nucleotide exchange factor(GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex(By similarity). Also acts as an activator for G(q)-alpha(GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

IMMUNOGEN INFORMATION

Immunogen

resistance to inhibitors of cholinesterase 8 homolog A(C. elegans)

Observed MW

58-62 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NPQ8

IMAGES

Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab07294(RIC8A antibody) at dilution of 1:50

human brain tissue were subjected to SDS PAGE followed by western blot with FNab07294(RIC8A antibody) at dilution of 1:200