anti- RNF4 antibody

anti- RNF4 antibody

Product Name

RNF4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'-and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

IMMUNOGEN INFORMATION

Immunogen

ring finger protein 4

Synonyms

SNURF

APPLICATION

Tested Application

ELISA, IP

Recommended Dilution

IP: 1:200-1:2000

UNIPROT INFORMATION

UniProt ID

P78317

IMAGES

IP Result of anti-RNF4 (IP:FNab07357, 4ug; Detection:FNab07357 1:300) with PC-3 cells lysate 3200ug.