anti- RSAD2 antibody

anti- RSAD2 antibody

Product Name

FNab07504

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Interferon-inducible iron-sulfur(4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus(HCMV), hepatitis C virus(HCV), west Nile virus(WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus(VSV), and human immunodeficiency virus(HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase(FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells(pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor(TCR)-mediated GATA3 activation and optimal T-helper 2(Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.

IMMUNOGEN INFORMATION

Immunogen

radical S-adenosyl methionine domain containing 2

Synonyms

2510004L01Rik, cig33, cig5, RSAD2, vig1, Viperin

Observed MW

45 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC

Recommended Dilution

WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q8WXG1

IMAGES

Immunohistochemistry of paraffin-embedded human skin using FNab07504(RSAD2 antibody) at dilution of 1:50

Immunofluorescent analysis of Hela cells, using RSAD2 antibody FNab07504 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

A549 cells were subjected to SDS PAGE followed by western blot with FNab07504(RSAD2 antibody) at dilution of 1:500